Thibodeau L, Lacroix M, Lecomte J, Fauvel M
Dev Biol Stand. 1984;57:157-63.
Nine neutralizing monoclonal antibodies were used in a preliminary study of the antigenic variation of poliovirus type 1. Six antigenic variants were selected and five distinct epitopes involved in neutralization were identified. Four of these epitopes are thought to be clustered within a single antigenic site. In kinetic studies, the neutralization of poliovirus by monoclonal antibodies was shown to be a single hit process.
九种中和性单克隆抗体被用于脊髓灰质炎1型病毒抗原变异的初步研究。挑选出六种抗原变体，并鉴定出五个参与中和作用的不同表位。其中四个表位被认为聚集在单一抗原位点内。在动力学研究中，单克隆抗体对脊髓灰质炎病毒的中和作用显示为单步过程。
