Shyrobokov V P, Kostenko I H, Nikolaienko I V
National Medical University, Kyiv, Ukraine.
Mikrobiol Z. 2003 Jul-Aug;65(4):29-36.
Hybridomes--producers of monoclonal antibodies (MAB) were obtained able to differentiate the variants Abent+ and Abent- poliovirus vaccine strain in the virus neutralizing reaction. Using the obtained panel the changes of the epitope structure of capsid proteins of poliovirus variants (dissociants) were found which appeared during reproduction in cell culture. It proves the fact that there exist essential antigenic differences of superficial virion's proteins, which appear during the process of dissociation.
