Daniel Ribeiro C, Alfred C, Monjour L, Gentilini M
Trop Geogr Med. 1984 Dec;36(4):323-8.
Sera from 280 inhabitants from the Upper-Volta villages of Donsé and Oursi were screened for the presence of anti-thyroglobulin antibodies (anti-Tg Ab) by the classical passive haemagglutination technique. Precipitant malarial antibodies and immunoglobulins (IgG, IgA, IgM) levels were concomitantly evaluated. Although 90% of the individuals studied had antibodies against malaria, a disease known to be associated with autoantibody (auto-Ab) production a normal frequency of anti-Tg Ab was observed in both Donsé and Oursi villages. This normal frequency of anti-Tg Ab contrasting to the previously reported increased frequency of other auto-Ab in individuals exposed to malaria, is additional evidence that the auto-Ab production that takes place during malaria infection is not the result of a generalized and non-specific activation of autoreactive cells by parasite derived mitogens.
采用经典被动血凝技术，对来自上沃尔特地区栋塞和乌尔西两个村庄的280名居民的血清进行抗甲状腺球蛋白抗体（anti-Tg Ab）筛查。同时评估沉淀性疟疾抗体和免疫球蛋白（IgG、IgA、IgM）水平。尽管90%的研究对象有抗疟疾抗体，而疟疾是一种已知与自身抗体（auto-Ab）产生有关的疾病，但在栋塞和乌尔西两个村庄中，抗Tg Ab的频率均正常。抗Tg Ab的这种正常频率与之前报道的接触疟疾个体中其他自身抗体频率增加形成对比，进一步证明疟疾感染期间发生的自身抗体产生并非寄生虫衍生的有丝分裂原对自身反应性细胞进行普遍非特异性激活的结果。
