Masukagami T, Ando K, Shimazaki J
Hinyokika Kiyo. 1984 Nov;30(11):1691-5.
We measured prostatic acid phosphatase levels by enzymeimmunoassay (PAP-EIA). Intraassay reproducibility of PAP-EIA was markedly good. In thirty normal males, PAP-EIA levels ranged from 0.24 ng/ml to 3.3 ng/ml, mean and S.D. being 0.94 ng/ml, 0.50 ng/ml, respectively. We made the upper limit of PAP-EIA for the normal range, 1.94 ng/ml (Mean + 2 S.D.). O 40 patients with untreated prostatic cancer, 34 patients (85%) gave positive results (1/3 33% of stage A, 3/4 75% B, 10/11 90% C, 20/22 90% D). One out of 12 patients with BPH, and one out of 11 with prostatitis gave positive results. The false positive rate was 9%. PAP levels of 324 samples from 111 patients with prostatic cancer were measured by EIA and radioimmunoassay (RIA). A significant correlation was noted between EIA and RIA (r = 0.997 p less than 0.001).
我们通过酶免疫测定法（PAP-EIA）测量前列腺酸性磷酸酶水平。PAP-EIA的批内重复性非常好。在30名正常男性中，PAP-EIA水平在0.24 ng/ml至3.3 ng/ml之间，平均值和标准差分别为0.94 ng/ml、0.50 ng/ml。我们将正常范围的PAP-EIA上限设定为1.94 ng/ml（平均值 + 2个标准差）。在40例未经治疗的前列腺癌患者中，34例（85%）结果呈阳性（A期1/3，33%；B期3/4，75%；C期10/11，90%；D期20/22，90%）。12例良性前列腺增生患者中有1例，11例前列腺炎患者中有1例结果呈阳性。假阳性率为9%。通过酶免疫测定法（EIA）和放射免疫测定法（RIA）对111例前列腺癌患者的324份样本进行了PAP水平测量。EIA和RIA之间存在显著相关性（r = 0.997，p < 0.001）。
