截肢与短小棒状杆菌对小鼠肿瘤转移的影响。
Effects of amputation and Corynebacterium parvum on tumour metastases in mice.
作者信息
Mosley J G, Sadler T E, Castro J E
出版信息
Br J Cancer. 1978 Apr;37(4):571-5. doi: 10.1038/bjc.1978.86.
The effects of operation (lower-limb amputation) on the growth of the Lewis lung tumour and its metastases were studied. The role of C. parvum in counteracting these effects was investigated. Anaesthesia alone or with amputation did not affect primary tumour growth. C. parvum depressed this growth. Anaesthesia did not affect the number of pulmonary metastases, but amputation caused a significant increase. C. parvum inhibited metastases and completely counteracted the effects of operation on them. Large doses of cortisone acetate significantly increased metastases but small doses had no effect. Experiments with adrenalectomized mice suggested the effects of operation were due to non-specific stress.
研究了手术（下肢截肢）对Lewis肺癌生长及其转移的影响。研究了微小隐孢子虫在抵消这些影响中的作用。单独麻醉或麻醉加截肢均不影响原发肿瘤的生长。微小隐孢子虫抑制了这种生长。麻醉不影响肺转移灶的数量，但截肢导致转移灶数量显著增加。微小隐孢子虫抑制转移，并完全抵消了手术对转移的影响。大剂量醋酸可的松显著增加转移灶数量，但小剂量则无影响。对肾上腺切除小鼠的实验表明，手术的影响是由于非特异性应激所致。
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