Scott M T
Dev Biol Stand. 1977;38:307-10.
Treatment of a chemically induced mouse solid fibrosarcoma using either non-specific (C. parvum 350 mu i.v.), or specific active (s.c. C. parvum mixed with 5.10(5) irradiated tumour cells) immunotherapy, 4 days after a single dose of cyclophosphamide (200 mg/kg) was synergistically more effective than either C. parvum or drug treatment alone. A contributory factor may be that cyclophosphamide pretreatment has been shown to potentiate the specific antitumour immunity that arises from C. parvum interaction with tumour antigen. Systemic C. parvum before cyclophosphamide will potentiate the antitumour effects of the drug--previously ineffective low doses becoming effective. No similar potentiation of the effects of another alkylating agent, Melphalan, was evident.
在单次给予环磷酰胺（200mg/kg）4天后，使用非特异性免疫疗法（静脉注射350μl微小隐孢子虫）或特异性主动免疫疗法（皮下注射微小隐孢子虫与5×10⁵个经照射的肿瘤细胞混合液）治疗化学诱导的小鼠实体纤维肉瘤，其协同效果比单独使用微小隐孢子虫或药物治疗更有效。一个促成因素可能是，已证明环磷酰胺预处理可增强微小隐孢子虫与肿瘤抗原相互作用产生的特异性抗肿瘤免疫力。在环磷酰胺之前进行全身性微小隐孢子虫治疗可增强药物的抗肿瘤作用——以前无效的低剂量变得有效。另一种烷化剂美法仑的作用没有明显的类似增强。
