Mayr A C, Westerhausen M, Senn H J
Dev Biol Stand. 1977;38:523-7.
Daily increasing intravenous doses of Corynebacterium parvum (C.p.) up to 5 mg/m2 i.v. X 10-14 days were given to 6 patients with widespread metastatic neoplastic diseases resistant to radio- and chemotherapy. The immunotherapy treatment-cycles were evaluated for toxic and immunologic side effects and also for possible clinical benefit to the patients. Immunotherapy with i.v.-C.p. was moderately well tolerated. Subjective discomfort for the patients (headache, chills, nausea) was not better tolerated with ongoing treatment-doses. After the 3rd day the body temperature rose nearly regularly to 40 degrees and more within 3-4 h after i.v.-C.p. and returned to normal levels about 6-10 h after the infusion was stopped. Hematological values were monitored on day 1, 4, 8, 15. WBC counts rose after an initial moderate decrease to normal levels. Monocyte counts rose also after an initial transient fall to pre-treatment levels. The monocytic activity index of Naphthol-AS-D-Chloro-Acetate-Esterase, correlating with the monocyte turnover, did not show a significant change. Granulocyte counts, especially stabs, increased slightly. Lymphocyte counts, the number and relations of B, T and O-cells, did not change in a uniform typical way. Hemoglobin values fell in all patients, reticulocyte counts increased, and the blood sedimentation rate did not change.
对6例对放疗和化疗耐药的广泛转移性肿瘤疾病患者，每日静脉注射递增剂量的短小棒状杆菌（C.p.），剂量高达5mg/m²，静脉注射，共10 - 14天。对免疫治疗周期进行了毒性和免疫副作用评估，以及对患者可能的临床获益评估。静脉注射C.p.的免疫治疗耐受性中等良好。随着治疗剂量的持续增加，患者的主观不适（头痛、寒战、恶心）并未得到更好的耐受。在第3天之后，静脉注射C.p.后3 - 4小时内，体温几乎有规律地升至40度及以上，并在输液停止后约6 - 10小时恢复到正常水平。在第1、4、8、15天监测血液学指标。白细胞计数在最初适度下降后升至正常水平。单核细胞计数在最初短暂下降至治疗前水平后也有所上升。与单核细胞周转率相关的萘酚 - AS - D - 氯乙酸酯酶单核细胞活性指数没有显著变化。粒细胞计数，尤其是杆状核粒细胞，略有增加。淋巴细胞计数、B细胞、T细胞和O细胞的数量及比例并没有以统一的典型方式发生变化。所有患者的血红蛋白值下降，网织红细胞计数增加，血沉率没有变化。
