Ryall R L
Department of Surgery, Flinders Medical Centre, Bedford Park, Adelaide, South Australia, Australia.
Pediatr Nephrol. 1996 Oct;10(5):656-66. doi: 10.1007/s004670050185.
The relative infrequency of renal stones in children is probably the main reason for the paucity of literature devoted to the study of urolithiasis in pediatric patients. Nonetheless, when pediatricians do address the issue, the contents of their papers reflect those prevalent in the adult literature; with one notable exception. Papers dealing with the potential role of urinary macromolecules in pediatric stone disease are very scarce indeed; to my knowledge, only four have been published in the English literature in the last 15 years. One of these is to be found in this issue and, like the remaining three, it compares the urinary excretion of glycosaminoglycans in healthy children and those with stones. This article briefly reviews the history of the association of urinary macromolecules, particularly glycosaminoglycans and proteins, with calcium oxalate urolithiasis, and discusses in more detail the published experimental evidence for their fulfilling a determinant role in stone formation.
儿童肾结石相对少见，这可能是致力于儿科患者尿石症研究的文献匮乏的主要原因。尽管如此，当儿科医生着手处理这个问题时，他们论文的内容反映出成人文献中普遍存在的情况，但有一个显著例外。关于尿大分子在儿童结石病中的潜在作用的论文确实非常稀少；据我所知，在过去15年里，英文文献中仅发表了4篇。本期中有其中一篇，和其余3篇一样，它比较了健康儿童和结石患儿的尿中糖胺聚糖的排泄情况。本文简要回顾了尿大分子，特别是糖胺聚糖和蛋白质与草酸钙尿石症关联的历史，并更详细地讨论了已发表的关于它们在结石形成中起决定性作用的实验证据。
