Chany C, Cerutti I
Med Oncol Tumor Pharmacother. 1984;1(2):101-7. doi: 10.1007/BF02934981.
The analysis of the likely physiological role of interferon during pregnancy and antitumor protection can be employed in developing a new strategy in antitumor therapy. Indeed, pretreatment of the patients with a potent immune stimulation compensates to some extent interferon's immune repressive effects. Through the modulation of the cytoskeleton, interferon enhances macrophage activity. Moreover, butyrate by its own effect on the malignant phenotype increases interferon sensitivity in a number of malignant cells. All of these substances should be used at the lowest possible concentration delivered as closely as possible to the target area.
对干扰素在孕期及抗肿瘤保护中可能的生理作用进行分析，可用于制定抗肿瘤治疗的新策略。实际上，用强效免疫刺激对患者进行预处理，在一定程度上可补偿干扰素的免疫抑制作用。通过调节细胞骨架，干扰素可增强巨噬细胞活性。此外，丁酸盐自身对恶性表型的作用可增加多种恶性细胞对干扰素的敏感性。所有这些物质都应以尽可能低的浓度使用，并尽可能靠近靶区域给药。
