dos Santos Neto F L, Volpon J B
Clin Orthop Relat Res. 1984 Jul-Aug(187):260-71.
A consistently reproducible nonunion was produced in mongrel dogs by resecting 3 mm of bone and 1 cm of periosteum at the diaphyseal-metaphyseal junction in the radius. Bone wax was used to seal the cut surfaces. No external or internal immobilization was necessary. The animals were sacrificed at various intervals up to one year after the operation. In one subgroup the events were assessed by radiologic and histologic techniques, and in another the limb was examined by microvascular and bone scintigraphic methods. Nonunion of the hypertrophic type occurred in 85% of cases and of the oligotrophic type in 15% of cases. Pseudarthrosis (with persistent mobility, neocapsule, synovial-like fluid, and well-differentiated cartilaginous tissue capping the bone ends) was established by the 28th week.
通过切除桡骨干骺端交界处3毫米的骨组织和1厘米的骨膜，在杂种狗中制造出一种可重复出现的骨不连。用骨蜡封闭切面。无需外部或内部固定。术后在长达一年的不同时间间隔处死动物。在一个亚组中，通过放射学和组织学技术评估情况，在另一个亚组中，通过微血管和骨闪烁扫描法检查肢体。85%的病例发生肥大性骨不连，15%的病例发生营养不良性骨不连。到第28周时形成了假关节（具有持续活动、新形成的关节囊、滑膜样液体以及覆盖骨端的分化良好的软骨组织）。
