McCulloch J, Kelly P A, van Delft A M
Eur J Pharmacol. 1982 Feb 26;78(2):151-8. doi: 10.1016/0014-2999(82)90231-x.
Adrenocorticotrophic hormone (ACTH) and structural analogs of the fragment ACTH4-9 have marked effects upon behavior (particularly in relation to memory processes). The effects of the chronic (10 day) administration of the potent analog (Met(O2)4,D-Lys8,Phe9]ACTH4-9(100 microgram/kg per day i.p,) upon local cerebral glucose utilization have been examined using the autoradiographic 2-deoxyglucose technique in the attempt to identify the neuroanatomical sites involved functionally in the central actions of this ACTH4-9 analog. Of the 49 anatomically discrete regions examined, significant increases in glucose utilization were observed only in the hippocampus (stratum molecular lacunosum lacunosum and parasubiculum, increased by 16 and 17% respectively), the anterior nucleus of the thalamus (by 23%) and anterior cingulate cortex (by 30%). The highly localized alterations in glucose utilization which were observed following treatment with this ACTH4-9 analog provide evidence for the functional involvement of a hippocampal-anterior-thalamic-anterior cingulate cortical circuit in the actions of this peptide fragment.
促肾上腺皮质激素（ACTH）以及ACTH4 - 9片段的结构类似物对行为（特别是与记忆过程相关的行为）有显著影响。已使用放射自显影2 - 脱氧葡萄糖技术研究了强效类似物[Met（O2）4，D - Lys8，Phe9]ACTH4 - 9（每天腹腔注射100微克/千克，持续10天）对局部脑葡萄糖利用的影响，以试图确定在功能上参与该ACTH4 - 9类似物中枢作用的神经解剖学部位。在所检查的49个解剖学上离散的区域中，仅在海马体（分子层、腔隙层和副下托，分别增加了16%和17%）、丘脑前核（增加了23%）和前扣带回皮质（增加了30%）观察到葡萄糖利用显著增加。用该ACTH4 - 9类似物治疗后观察到的葡萄糖利用高度局部性改变，为海马 - 丘脑前 - 前扣带回皮质回路在该肽片段作用中的功能参与提供了证据。
