Wilber J F, Spinella P
J Clin Endocrinol Metab. 1984 Sep;59(3):432-5. doi: 10.1210/jcem-59-3-432.
Immunoreactive TRH (IR-TRH) was identified in extracts derived from seven human cancer tissues, including two oat cell carcinomas. The IR-TRH concentrations ranged from 29-189 pg/g. Tumor IR-TRH exhibited immunological identity with synthetic pyroglu-his-proamide and coeluted with synthetic [3H]TRH after high pressure liquid chromatography on a mu Bondapak C-18 column. These data extend the number of hypothalamic peptide hormones identified in human neoplastic tissues.
在取自七种人类癌组织（包括两例燕麦细胞癌）的提取物中鉴定出了免疫反应性促甲状腺激素释放激素（IR-TRH）。IR-TRH浓度范围为29 - 189 pg/g。肿瘤IR-TRH与合成的焦谷氨酸-组氨酸-脯氨酰胺呈现免疫学同一性，并且在μ Bondapak C - 18柱上进行高压液相色谱分析后与合成的[³H]TRH共洗脱。这些数据扩展了在人类肿瘤组织中鉴定出的下丘脑肽类激素的数量。
