Department of Surgical Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.
Scientific Direction, IRCCS San Gallicano Dermatological Institute, 00144 Rome, Italy.
Int J Mol Sci. 2022 Sep 2;23(17):10036. doi: 10.3390/ijms231710036.
Clinical and epidemiological evidence indicate a relationship between thyroid diseases and melanoma. In particular, the hypothyroidism condition appears to promote melanoma spread, which suggests a protective role of thyroid hormones against disease progression. In addition, experimental data suggest that, in addition to thyroid hormones, other hormonal players of the hypothalamic-pituitary-thyroid (HPT) axis, namely the thyrotropin releasing hormone and the thyrotropin, are likely to affect melanoma cells behavior. This information warrants further clinical and experimental studies in order to build a precise pattern of action of the HPT hormones on melanoma cells. An improved knowledge of the involved molecular mechanism(s) could lead to a better and possibly personalized clinical management of these patients.
临床和流行病学证据表明甲状腺疾病与黑色素瘤之间存在关联。特别是，甲状腺功能减退症的情况似乎会促进黑色素瘤的扩散，这表明甲状腺激素对疾病进展具有保护作用。此外，实验数据表明，除了甲状腺激素外，下丘脑-垂体-甲状腺（HPT）轴的其他激素参与者，即促甲状腺素释放激素和促甲状腺素，也可能影响黑色素瘤细胞的行为。为了构建 HPT 激素对黑色素瘤细胞作用的确切模式，有必要进一步开展临床和实验研究。更好地了解相关的分子机制（多个）可能会导致对这些患者进行更好和可能个性化的临床管理。
