Ohmann H B, Babiuk L A
J Interferon Res. 1984 Spring;4(2):249-63. doi: 10.1089/jir.1984.4.249.
Bovine phagocytic cells (polymorphonuclear granulocytes, blood monocytes and alveolar macrophages) were treated in vitro with homogeneous, recombinant DNA produced bovine alpha-1 interferon (IFN-alpha 1). The effects seen comprised of enhanced bacterial uptake by all three cell types and increased Fc receptor activity in alveolar macrophages, inhibition of both directed and random migration of monocytes and polymorphs, increased enzyme release or inactivation, increased hydrogen peroxide generation, and decreased superoxide anion release by alveolar macrophages and polymorphonuclear leukocytes. These effects were dose- and time-dependent, the kinetics varying for the different cell types.
用同源重组DNA产生的牛α-1干扰素（IFN-α1）对牛吞噬细胞（多形核粒细胞、血液单核细胞和肺泡巨噬细胞）进行体外处理。观察到的效应包括所有三种细胞类型的细菌摄取增强以及肺泡巨噬细胞中Fc受体活性增加，单核细胞和多形核细胞的定向和随机迁移受到抑制，酶释放或失活增加，过氧化氢生成增加，以及肺泡巨噬细胞和多形核白细胞的超氧阴离子释放减少。这些效应呈剂量和时间依赖性，不同细胞类型的动力学有所不同。
