Takimoto T, Morishita K, Umeda R, Ogura H, Hatano M
ORL J Otorhinolaryngol Relat Spec. 1984;46(4):195-201. doi: 10.1159/000275709.
The pathogenesis of nasopharyngeal carcinoma caused by the Epstein-Barr virus (EBV) has been studied experimentally by infecting monolayer cells derived from human normal nasopharynx with the B-lymphotropic EBV. Direct EBV infection of the cell sheets derived from the human nasopharynx resulted in the appearance of EBV-associated nuclear antigen-positive floating cells, suggesting that the monolayer cells have been transformed. Since these cells seemed to be of the B-type lymphocyte, it may be assumed that there must have been B lymphocytes among the cells of the monolayer which have undergone transformation by the virus. EBV infection of fused human epithelial cells (Ad-AH and D98-AH cells) and B-lymphoblastoid cells (BJAB cells) showed that the EBV receptors had been maintained for no longer than 24 h even when heterokaryons and hybrid cells were formed.
通过用人嗜B淋巴细胞性EB病毒感染源自人正常鼻咽部的单层细胞，对EB病毒（EBV）引起鼻咽癌的发病机制进行了实验研究。EB病毒直接感染源自人鼻咽部的细胞片层，导致出现EB病毒相关核抗原阳性的漂浮细胞，这表明单层细胞已被转化。由于这些细胞似乎是B型淋巴细胞，因此可以推测，在单层细胞中必定存在已被病毒转化的B淋巴细胞。EB病毒感染融合的人上皮细胞（Ad-AH和D98-AH细胞）和B淋巴母细胞样细胞（BJAB细胞）表明，即使形成了异核体和杂交细胞，EB病毒受体也只能维持不超过24小时。
