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[含刺种培养物作为百日咳成分的吸附无细胞百日咳疫苗反应原性的有限对照试验]

[Limited controlled trial of the reactogenic properties of ADTP vaccines containing stab cultures as the pertussis component].

作者信息

Shmeleva E I, Remova T N, Baeva E A, Salmin L V, Selezneva V P

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1984 Jun(6):68-73.

PMID:6087580
Abstract

The reactogenic properties of adsorbed DPT vaccine containing Bordetella pertussis cultures, grown by submerged cultivation, as the pertussis component were studied. The study revealed that the vaccine was low-reactogenic: no severe postvaccinal reactions were recorded in immunized children. The frequency and intensity of febrile and local reactions in children immunized with adsorbed DPT vaccine under trial and the commercial preparation commonly used in the USSR were identical, but considerably less pronounced than in children immunized with foreign vaccines having similar composition.

摘要

对含有通过深层培养法培养的百日咳博德特氏菌培养物作为百日咳成分的吸附白百破疫苗的反应原性特性进行了研究。研究表明该疫苗反应原性较低:在免疫儿童中未记录到严重的接种后反应。试验中的吸附白百破疫苗和苏联常用的商业制剂免疫儿童中发热和局部反应的频率及强度相同,但比接种成分相似的国外疫苗的儿童中明显要轻得多。

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