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Omeprazole, a gastric 'proton pump inhibitor': lack of effect on renal handling of electrolytes and urinary acidification.

作者信息

Howden C W, Reid J L

出版信息

Eur J Clin Pharmacol. 1984;26(5):639-40. doi: 10.1007/BF00543501.

DOI:10.1007/BF00543501
PMID:6088253
Abstract

Omeprazole has previously been shown to be a potent inhibitor of gastric acid secretion in man. In a new study, oral omeprazole 60 mg/day was given to 8 healthy male subjects for 8 days. The daily urinary electrolyte output and urine pH in response to ammonium chloride were not significantly altered. This provides further support for the specificity of its action on gastric acid secretion.

摘要

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Omeprazole, a gastric 'proton pump inhibitor': lack of effect on renal handling of electrolytes and urinary acidification.
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2
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本文引用的文献

1
Effect of omeprazole--a gastric proton pump inhibitor--on pentagastrin stimulated acid secretion in man.奥美拉唑（一种胃质子泵抑制剂）对人五肽胃泌素刺激的胃酸分泌的影响。
Gut. 1983 Apr;24(4):270-6. doi: 10.1136/gut.24.4.270.
2
Effects of single and repeated doses of omeprazole on gastric acid and pepsin secretion in man.单次及重复剂量奥美拉唑对人体胃酸和胃蛋白酶分泌的影响。
Gut. 1984 Jul;25(7):707-10. doi: 10.1136/gut.25.7.707.
3
Effect of daily oral omeprazole on 24 hour intragastric acidity.每日口服奥美拉唑对24小时胃内酸度的影响。
Int J Mol Sci. 2019 Oct 21;20(20):5203. doi: 10.3390/ijms20205203.
4
Kidney biopsy for renal tubular acidosis: when tissue diagnosis makes a difference.肾小管酸中毒的肾活检：组织诊断何时起重要作用。
Clin Nephrol Case Stud. 2015 May 22;3:1-4. doi: 10.5414/CNCS108412. eCollection 2015.
5
PPIs and kidney disease: from AIN to CKD.质子泵抑制剂与肾脏疾病：从急性间质性肾炎到慢性肾脏病
J Nephrol. 2016 Oct;29(5):611-6. doi: 10.1007/s40620-016-0309-2. Epub 2016 Apr 12.
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[Follow-up care - consequences of urinary diversion after bladder cancer].[随访护理——膀胱癌尿路改道的后果]
Urologe A. 2014 Feb;53(2):253-62; quiz 263-4. doi: 10.1007/s00120-013-3376-1.
7
Electrolyte disturbance with omeprazole therapy.奥美拉唑治疗引起的电解质紊乱。
Eur J Pediatr. 1994 Jan;153(1):49-51. doi: 10.1007/BF02000787.
8
Safety of acid-suppressing drugs.抑酸药物的安全性。
Dig Dis Sci. 1995 Feb;40(2 Suppl):63S-80S. doi: 10.1007/BF02214872.
9
Pharmacokinetic optimisation of the treatment of peptic ulcer in patients with renal failure.肾衰竭患者消化性溃疡治疗的药代动力学优化
Clin Pharmacokinet. 1994 Nov;27(5):393-408. doi: 10.2165/00003088-199427050-00006.
10
Antisecretory effect and oral pharmacokinetics of omeprazole in patients with chronic renal failure.
Eur J Clin Pharmacol. 1985;28(6):637-40. doi: 10.1007/BF00607907.
Br Med J (Clin Res Ed). 1983 Jul 2;287(6384):12-4. doi: 10.1136/bmj.287.6384.12.
4
Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+)ATPase.取代苯并咪唑通过阻断（H⁺+K⁺）ATP酶来抑制胃酸分泌。
Nature. 1981 Mar 12;290(5802):159-61. doi: 10.1038/290159a0.
5
Rapid healing of duodenal ulcers with omeprazole: double-blind dose-comparative trial.奥美拉唑治疗十二指肠溃疡的快速愈合：双盲剂量对比试验。
Lancet. 1983 Jul 16;2(8342):124-5. doi: 10.1016/s0140-6736(83)90114-9.
6
Characterization of gastric mucosal membranes. X. Immunological studies of gastric (H+ + K+)-ATPase.胃黏膜膜的特性。X. 胃（H⁺ + K⁺）-ATP酶的免疫学研究。
J Cell Biol. 1979 Nov;83(2 Pt 1):271-83. doi: 10.1083/jcb.83.2.271.