Rumpf K W, Rieger J, Doht B, Ansorg R, Scheler F
J Dial. 1977;1(7):677-8. doi: 10.3109/08860227709037663.
Elimination by hemofiltration of gentamicin, doxycylin, ampicillin, sulfamethoxazole and clofibrate was measured in patients with chronic renal insufficiency. Clearance values of ampicillin and clofibrate were roughly in the range that might be expected according to the reported protein binding values of these drugs, whereas doxycyclin and sulfamethoxazole were eliminated to a much higher degree. Gentamicin clearances during a 6-hour hemofiltration treatment were lower than should be expected from reported protein binding values. For gentamicin and doxycyclin the filtered fraction linearly increased with time, a phenomenon which may be explained by membrane polarization.
在慢性肾功能不全患者中测定了通过血液滤过清除庆大霉素、强力霉素、氨苄青霉素、磺胺甲恶唑和氯贝丁酯的情况。氨苄青霉素和氯贝丁酯的清除率值大致在根据这些药物报道的蛋白结合值所预期的范围内，而强力霉素和磺胺甲恶唑的清除程度要高得多。在6小时血液滤过治疗期间庆大霉素的清除率低于根据报道的蛋白结合值所预期的值。对于庆大霉素和强力霉素，滤过分数随时间呈线性增加，这种现象可能由膜极化来解释。
