氨曲南和头孢噻肟在纯培养和混合培养中对大肠杆菌和拟杆菌属的比较活性。
Comparative activities of aztreonam and cefotaxime against Escherichia coli and Bacteroides spp. in pure and mixed cultures.
作者信息
Soriano F, Ponte M C
出版信息
Antimicrob Agents Chemother. 1984 Jul;26(1):39-41. doi: 10.1128/AAC.26.1.39.
Abstract
The activities of aztreonam and cefotaxime against one Escherichia coli strain and three Bacteroides strains have been studied by using pure and mixed cultures of aerobic and anaerobic bacteria. A fixed concentration (8 micrograms/ml) of cefotaxime or aztreonam killed E. coli that was exposed in pure culture, but the pressure of Bacteroides spp. in the same system deteriorated cefotaxime, allowing the full growth of E. coli after 24 h. On the other hand, the presence of Bacteroides spp. produced less deterioration of aztreonam, which reduced the initial E. coli inoculum. This observation could be useful in clinical practice when treating mixed aerobic and anaerobic infections.
摘要
通过使用需氧菌和厌氧菌的纯培养物及混合培养物，研究了氨曲南和头孢噻肟对一株大肠杆菌菌株和三株拟杆菌菌株的活性。固定浓度（8微克/毫升）的头孢噻肟或氨曲南能杀死纯培养物中暴露的大肠杆菌，但同一系统中拟杆菌属的存在会使头孢噻肟降解，导致24小时后大肠杆菌完全生长。另一方面，拟杆菌属的存在对氨曲南的降解作用较小，氨曲南能减少初始大肠杆菌接种量。这一观察结果在治疗需氧菌和厌氧菌混合感染的临床实践中可能有用。
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