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Biophys J. 1984 Aug;46(2):249-52. doi: 10.1016/S0006-3495(84)84017-5.
2
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3
Ion transport in the simplest single file pore.最简单的单通道孔中的离子运输。
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4
Flux, coupling, and selectivity in ionic channels of one conformation.单一构象离子通道中的通量、偶联和选择性。
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Multioccupancy models for single filing ionic channels: theoretical behavior of a four-site channel with three barriers separating the sites.单通道离子通道的多占据模型：具有三个分隔位点的屏障的四位点通道的理论行为。
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Conformational model for ion permeation in membrane channels: a comparison with multi-ion models and applications to calcium channel permeability.膜通道离子渗透的构象模型：与多离子模型的比较及对钙通道通透性的应用
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Interactions of protons with single open L-type calcium channels. Location of protonation site and dependence of proton-induced current fluctuations on concentration and species of permeant ion.质子与单个开放的L型钙通道的相互作用。质子化位点的位置以及质子诱导的电流波动对渗透离子浓度和种类的依赖性。
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本文引用的文献

1
The influence of the permeant ions thallous and potassium on inward rectification in frog skeletal muscle.通透离子铊离子和钾离子对青蛙骨骼肌内向整流的影响。
J Physiol. 1983 Oct;343:407-28. doi: 10.1113/jphysiol.1983.sp014900.
2
Fluctuations of barrier structure in ionic channels.离子通道中屏障结构的波动。
Biochim Biophys Acta. 1980 Oct 16;602(1):167-80. doi: 10.1016/0005-2736(80)90299-0.
3
Kinetic properties of ion carriers and channels.离子载体和通道的动力学特性。
J Membr Biol. 1980 Dec 30;57(3):163-78(-RETURN-). doi: 10.1007/BF01869585.
4
Ion transfer across lipid membranes in the presence of gramicidin A. II. The ion selectivity.短杆菌肽A存在下离子在脂质膜上的转运。II. 离子选择性。
Biochim Biophys Acta. 1972 Aug 9;274(2):313-22. doi: 10.1016/0005-2736(72)90179-4.
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Ion transport through pores: a rate-theory analysis.离子通过孔道的传输：速率理论分析
Biochim Biophys Acta. 1973 Jul 6;311(3):423-41. doi: 10.1016/0005-2736(73)90323-4.
6
Potassium channels as multi-ion single-file pores.作为多离子单排孔道的钾通道。
J Gen Physiol. 1978 Oct;72(4):409-42. doi: 10.1085/jgp.72.4.409.
7
Anomalous permeabilities of the egg cell membrane of a starfish in K+-Tl+ mixtures.海星卵细胞在钾离子-铊离子混合物中的异常渗透性。
J Gen Physiol. 1977 Sep;70(3):269-81. doi: 10.1085/jgp.70.3.269.
8
Ionic selectivity, saturation, and block in gramicidin A channels. II. Saturation behavior of single channel conductances and evidence for the existence of multiple binding sites in the channel.
J Membr Biol. 1978 Apr 26;40(2):97-116. doi: 10.1007/BF01871143.
9
Ionic selectivity, saturation and block in gramicidin A channels: I. Theory for the electrical properties of ion selective channels having two pairs of binding sites and multiple conductance states.短杆菌肽A通道中的离子选择性、饱和性和阻断作用：I. 具有两对结合位点和多个电导状态的离子选择性通道电特性的理论
J Membr Biol. 1977 Mar 23;31(4):383-47. doi: 10.1007/BF01869414.

具有波动能量分布的单粒子孔中通量之间的耦合。一项理论研究。

Coupling between fluxes in one-particle pores with fluctuating energy profiles. A theoretical study.

作者信息

Ciani S

出版信息

Biophys J. 1984 Aug;46(2):249-52. doi: 10.1016/S0006-3495(84)84017-5.

DOI:10.1016/S0006-3495(84)84017-5
PMID:6089924
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1435027/
Abstract

We show theoretically that extending pore models to allow for fluctuations between configurations with different energy profiles results in the prediction of coupling between fluxes and forces of different species diffusing through singly occupied pores. Considering the case of a one-site, two-barrier pore capable of existing in two states, and using Eyring rate theory to describe the translocation of two permeant species, the flux of each is found to be linked to the driving force of the other via cross coefficients that are given as explicit functions of concentrations and potential, and that obey Onsager's relations when the system is near equilibrium. Conditions for the existence of coupling are that both states of the channel be permeable to both diffusing species and that the peaks of the two energy barrier shift by different amounts during the state transition of the pore. Some implications of this model on phenomena of biological interest are discussed briefly.

摘要

我们从理论上表明，扩展孔隙模型以允许具有不同能量分布的构型之间的波动，会导致预测通过单占据孔隙扩散的不同物种的通量与力之间的耦合。考虑一个能够以两种状态存在的单点双势垒孔隙的情况，并使用艾林速率理论来描述两种渗透物种的转运，发现每种物种的通量通过交叉系数与另一种物种的驱动力相关联，这些交叉系数是浓度和电位的显式函数，并且当系统接近平衡时服从昂萨格关系。耦合存在的条件是通道的两种状态对两种扩散物种都具有渗透性，并且在孔隙的状态转变期间两个能量势垒的峰值移动不同的量。简要讨论了该模型对生物学相关现象的一些影响。