Lukoshkova E V, Kryzhanovskaia E G, Karpova M N
Biull Eksp Biol Med. 1981;91(1):35-7.
It was shown in experiments on cats that when strophanthin K injected intravenously induced ventricular arrhythmias followed by an insignificant reduction of the sympathetic activity (recorded from the cardiac nerve), lithium chloride and lithium hydroxybutyrate did not produce any effect on arrhythmia but lowered the sympathetic activity. When strophanthin-induced arrhythmias were accompanied by an increase in the sympathetic activity (animals with vagus section and denervation of the sinocarotid and cardioaortal zones), lithium hydroxybutyrate led to the diminution of the sympathetic activity and exerted antiarrhythmic effects. It is concluded that in the mechanisms of the antiarrhythmic effect an important role belongs to its depressant effect on the hyperactivated adrenergic extracardiac apparatus.
在猫身上进行的实验表明，静脉注射毒毛花苷 K 诱发室性心律失常后，交感神经活动（从心脏神经记录）略有降低，此时氯化锂和羟丁酸锂对心律失常没有任何影响，但会降低交感神经活动。当毒毛花苷诱发的心律失常伴有交感神经活动增加时（迷走神经切断以及窦颈动脉和心主动脉区去神经支配的动物），羟丁酸锂会导致交感神经活动减弱并发挥抗心律失常作用。得出的结论是，在抗心律失常作用机制中，其对过度激活的心脏外肾上腺素能装置的抑制作用起着重要作用。
