Rowan-Kelly B, Ferrante A, Thong Y H
Int J Immunopharmacol. 1984;6(4):389-93. doi: 10.1016/0192-0561(84)90059-6.
The effect of five imidazole derivatives (metronidazole, tinidazole, clotrimazole, miconazole and ketoconazole) on human polymorphonuclear leucocytes (PMNL) was examined in vitro. Metronidazole and tinidazole had no apparent effect on either PMNL chemotactic response or PMNL fungal/bacterial killing. In contrast, clotrimazole, miconazole and ketoconazole inhibited PMNL chemotaxis. In addition, miconazole and ketoconazole were shown to depress the ability of PMNL to kill bacteria and fungi.
体外研究了五种咪唑衍生物（甲硝唑、替硝唑、克霉唑、咪康唑和酮康唑）对人多形核白细胞（PMNL）的影响。甲硝唑和替硝唑对PMNL的趋化反应或PMNL对真菌/细菌的杀伤作用均无明显影响。相比之下，克霉唑、咪康唑和酮康唑抑制PMNL趋化作用。此外，咪康唑和酮康唑还被证明会降低PMNL杀伤细菌和真菌的能力。
