Tajima K, Akaza T, Koike K, Hinuma Y, Suchi T, Tominaga S
Jpn J Clin Oncol. 1984 Sep;14(3):347-52.
In order to study the genetical susceptibility to infection by adult T-cell leukemia virus (ATLV), which is considered to be a main causative agent of adult T-cell leukemia (ATL), the HLA profile of persons with antibody against ATLV-associated antigen (anti-ATLA) was compared with that of antibody-negative persons in villages A and B of the Goto Islands, a typical ATL endemic area in Kyushu, Japan. The frequency (29%) of HLA-B7 in persons with anti-ATLA was significantly higher than that (8%) in anti-ATLA negatives (corrected X2 = 7.73, p less than 0.01) in one village while the frequency of HLA-B7 was around 10% in both positive and negative persons in the other village. These results do not support or deny the possibility of the existence of individuals who are genetically susceptible to ATLV infection in ATL endemic areas of Japan.
为了研究成人T细胞白血病病毒（ATLV）感染的遗传易感性，成人T细胞白血病病毒被认为是成人T细胞白血病（ATL）的主要致病因子，在日本九州典型的ATL流行地区五岛列岛的A村和B村，对具有抗ATLV相关抗原抗体（抗ATLA）的人和抗体阴性的人的HLA谱进行了比较。在一个村庄中，抗ATLA的人HLA - B7的频率（29%）显著高于抗ATLA阴性的人（8%）（校正X2 = 7.73，p小于0.01），而在另一个村庄中，阳性和阴性人群中HLA - B7的频率均约为10%。这些结果既不支持也不否认在日本ATL流行地区存在对ATLV感染具有遗传易感性个体的可能性。
Zotero 插件