[成人T细胞白血病病毒（ATLV）——一项血清学研究]

[Adult T cell leukemia virus (ATLV)--a serological study].

作者信息

Hinuma Y

出版信息

Gan To Kagaku Ryoho. 1982 Aug;9(8):1313-20.

Abstract

A nation-wide sero-epidemiologic survey of adult T-cell leukemia virus (ATLV) detected as anti-ATLA (ATLV-associated antigen) was made in Japan. Sera from adult donors in 15 different locations were screened for anti-ATLA. High incidences (6 to 37%) of antibody-positive donors were found in seven regions, one in northern Japan, and the others in southwestern regions. These areas are ATLV-endemic areas corresponding to ATL-endemic areas. Examination of sera from healthy donors aged 6 to 80 years in ATL-endemic areas showed an age-dependent increase of seropositive donors with a maximum of about 30% at 40 years of age. Anti-ATLA was found in all but two of 142 patients with ATL. Anti-ATLA-positive patients with ATL were mainly found in ATLV-endemic areas, and only a few in ATL-nonendemic areas. Six patients with cutaneous T-cell lymphoma in ATLV-nonendemic areas gave a negative reaction for anti-ATLA. The geometric mean titer of anti-ATLA of patients with ATL was higher than that of healthy donors.

摘要

在日本针对成人T细胞白血病病毒（ATLV）开展了一项全国性血清流行病学调查，该病毒通过抗ATLA（ATLV相关抗原）检测。对来自15个不同地区的成年献血者血清进行了抗ATLA筛查。在七个地区发现抗体阳性献血者的比例较高（6%至37%），其中一个在日本北部，其他在西南部地区。这些地区是与成人T细胞白血病（ATL）流行区相对应的ATLV流行区。对ATL流行区6至80岁健康献血者的血清检测显示，血清阳性献血者随年龄增长而增加，40岁时最高约为30%。在142例ATL患者中，除2例之外均检测到抗ATLA。抗ATLA阳性的ATL患者主要出现在ATLV流行区，在ATL非流行区仅有少数。ATLV非流行区的6例皮肤T细胞淋巴瘤患者抗ATLA检测呈阴性反应。ATL患者抗ATLA的几何平均滴度高于健康献血者。