人类T细胞白血病病毒3'末端区域的表达
Expression of the 3' terminal region of human T-cell leukemia viruses.
作者信息
Wachsman W, Shimotohno K, Clark S C, Golde D W, Chen I S
出版信息
Science. 1984 Oct 12;226(4671):177-9. doi: 10.1126/science.6091270.
PMID:6091270
Abstract
Human T-cell leukemia viruses (HTLV) are closely associated with some human T-cell leukemias and lymphomas. A unique 3' region of the HTLV genome is believed to be involved in HTLV-induced cellular transformation, although the function of this region has yet to be determined. A subgenomic messenger RNA transcribed from this region of HTLV has now been characterized. These results provide direct evidence for the expression of a novel gene in HTLV.
摘要
人类T细胞白血病病毒（HTLV）与某些人类T细胞白血病和淋巴瘤密切相关。尽管HTLV基因组独特的3'区域的功能尚未确定，但据信它参与了HTLV诱导的细胞转化。现在已经对从HTLV这个区域转录的亚基因组信使RNA进行了表征。这些结果为HTLV中一个新基因的表达提供了直接证据。
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