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人类T细胞白血病病毒长末端重复序列的反式激活与x-lor蛋白的表达相关。

trans-Activation of the human T-cell leukemia virus long terminal repeat correlates with expression of the x-lor protein.

作者信息

Sodroski J G, Goh W C, Rosen C A, Salahuddin S Z, Aldovini A, Franchini G, Wong-Staal F, Gallo R C, Sugamura K, Hinuma Y

出版信息

J Virol. 1985 Sep;55(3):831-5. doi: 10.1128/JVI.55.3.831-835.1985.

DOI:10.1128/JVI.55.3.831-835.1985
PMID:2991599
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC255069/
Abstract

Cell lines established directly from adult T-cell leukemia-lymphoma patients or immortalized by human T-cell leukemia virus type I (HTLV-I) in vitro that do not produce complete HTLV virions were characterized both for the content of viral proteins and for the presence of trans-acting factors activating gene expression under the control of the HTLV long terminal repeat. The expression of the 42-kilodalton HTLV x-lor product correlated with trans-activation of the long terminal repeat. The implications of this study for understanding the role of the HTLV x-lor product in the initiation and maintenance of T-lymphocyte transformation are discussed.

摘要

直接从成人T细胞白血病-淋巴瘤患者建立的细胞系，或在体外被I型人类T细胞白血病病毒（HTLV-I）永生化且不产生完整HTLV病毒粒子的细胞系，就病毒蛋白含量以及在HTLV长末端重复序列控制下激活基因表达的反式作用因子的存在情况进行了表征。42千道尔顿HTLV x-lor产物的表达与长末端重复序列的反式激活相关。讨论了本研究对于理解HTLV x-lor产物在T淋巴细胞转化起始和维持中的作用的意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8088/255069/70c6a7e9d7dd/jvirol00120-0327-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8088/255069/100c3e982d4b/jvirol00120-0326-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8088/255069/23c964a8bd76/jvirol00120-0327-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8088/255069/70c6a7e9d7dd/jvirol00120-0327-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8088/255069/100c3e982d4b/jvirol00120-0326-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8088/255069/23c964a8bd76/jvirol00120-0327-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8088/255069/70c6a7e9d7dd/jvirol00120-0327-b.jpg

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本文引用的文献

1
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Nature. 1982 Nov 4;300(5887):63-6. doi: 10.1038/300063a0.
2
A new subtype of human T-cell leukemia virus (HTLV-II) associated with a T-cell variant of hairy cell leukemia.一种与毛细胞白血病的T细胞变异型相关的人类T细胞白血病病毒（HTLV-II）新亚型。
Science. 1982 Nov 5;218(4572):571-3. doi: 10.1126/science.6981847.
3
Transformation of human leukocytes by cocultivation with an adult T cell leukemia virus producer cell line.
1型人类T细胞白血病/淋巴瘤病毒对T细胞的控制
Int J Hematol. 2003 Nov;78(4):280-96. doi: 10.1007/BF02983552.
4
Transcriptional up-regulation of the cyclin D2 gene and acquisition of new cyclin-dependent kinase partners in human T-cell leukemia virus type 1-infected cells.人1型嗜T细胞白血病病毒感染细胞中细胞周期蛋白D2基因的转录上调及新的细胞周期蛋白依赖性激酶伙伴的获得
J Virol. 1999 Dec;73(12):9917-27. doi: 10.1128/JVI.73.12.9917-9927.1999.
5
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Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3536-41. doi: 10.1073/pnas.93.8.3536.
6
Identification of two distinct elements in the long terminal repeat of HTLV-I responsible for maximum gene expression.鉴定出人类嗜T淋巴细胞病毒I型（HTLV-I）长末端重复序列中负责最大基因表达的两个不同元件。
EMBO J. 1987 Feb;6(2):389-95. doi: 10.1002/j.1460-2075.1987.tb04767.x.
7
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J Virol. 1987 Apr;61(4):1171-9. doi: 10.1128/JVI.61.4.1171-1179.1987.
8
trans activation of an Epstein-Barr viral transcriptional enhancer by the Epstein-Barr viral nuclear antigen 1.爱泼斯坦-巴尔病毒核抗原1对爱泼斯坦-巴尔病毒转录增强子的反式激活作用。
Mol Cell Biol. 1986 Nov;6(11):3838-46. doi: 10.1128/mcb.6.11.3838-3846.1986.
9
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10
Inhibition of replication and expression of human T-cell lymphotropic virus type III in cultured cells by exogenous synthetic oligonucleotides complementary to viral RNA.外源性合成的与病毒RNA互补的寡核苷酸对培养细胞中人嗜T细胞病毒III型复制和表达的抑制作用。
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5
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Mol Cell Biol. 1982 Sep;2(9):1044-51. doi: 10.1128/mcb.2.9.1044-1051.1982.
6
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7
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Virology. 1983 Aug;129(1):51-64. doi: 10.1016/0042-6822(83)90395-1.
8
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Nature. 1983;305(5932):340. doi: 10.1038/305340a0.
9
Cell-specific expression controlled by the 5'-flanking region of insulin and chymotrypsin genes.由胰岛素基因和胰凝乳蛋白酶基因的5'侧翼区域控制的细胞特异性表达。
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10
Structure of 3' terminal region of type II human T lymphotropic virus: evidence for new coding region.人类嗜T淋巴细胞病毒II型3'末端区域的结构：新编码区的证据
Science. 1984 Jul 27;225(4660):419-21. doi: 10.1126/science.6330894.