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细小病毒引起的幼犬心肌炎导致的猝死。

Sudden death in young dogs with myocarditis caused by parvovirus.

作者信息

Hayes M A, Russell R G, Babiuk L A

出版信息

J Am Vet Med Assoc. 1979 Jun 1;174(11):1197-203.

PMID:438048
Abstract

Sudden death of pups in the 4- to 6-week age range has recently been occurring in western Canada as a result of severe, primary, nonsuppurative myocarditis. At necropsy, the prominent macroscopic lesion was pulmonary edema, and microscopically, characteristic intranuclear inclusion bodies were found within cardiac myofibers in association with myocarditis. Ultrastructurally, numerous small particles resembling parvoviruses were found within the intranuclear inclusion bodies, which were positive by direct fluorescent antibody test for canine parvovirus. Of three pups inoculated with homogenate from affected myocardium, one developed lesions resembling canine parvoviral enteritis.

摘要

最近在加拿大西部,4至6周龄幼犬突然死亡,原因是严重的原发性非化脓性心肌炎。尸检时,突出的宏观病变是肺水肿,显微镜下,在与心肌炎相关的心肌纤维内发现了特征性的核内包涵体。超微结构上,在核内包涵体内发现了许多类似细小病毒的小颗粒,通过犬细小病毒直接荧光抗体检测呈阳性。在三只接种了受影响心肌匀浆的幼犬中,有一只出现了类似犬细小病毒性肠炎的病变。

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