对患有实验性脑脊髓炎的大鼠体内鼠肝炎病毒（JHM）RNA的特性分析。
Characterization of murine hepatitis virus (JHM) RNA from rats with experimental encephalomyelitis.
作者信息
Jackson D P, Percy D H, Morris V L
出版信息
Virology. 1984 Sep;137(2):297-304. doi: 10.1016/0042-6822(84)90221-6.
Abstract
When Wistar Furth rats are inoculated intracerebrally with the murine hepatitis virus JHM they often develop a demyelinating disease with resulting hind leg paralysis. Using an RNA transfer procedure and hybridization kinetic analysis, the virus-specific RNA in these rats was characterized. The pattern of JHM-specific RNA varied with individual infections of Wistar Furth rats. However, two species of JHM-specific RNA, the nucleocapsid and a 2.1-2.4 X 10(6)-Da RNA species were generally present. A general decrease in JHM-specific RNA in brains and spinal cord samples taken later than 20 days postinoculation was observed; however, JHM-specific RNA persisted in the spinal cord longer than in the brain of these rats.
摘要
当用鼠肝炎病毒JHM对Wistar Furth大鼠进行脑内接种时，它们常常会患上一种脱髓鞘疾病，导致后腿麻痹。通过RNA转移程序和杂交动力学分析，对这些大鼠体内的病毒特异性RNA进行了表征。JHM特异性RNA的模式因Wistar Furth大鼠的个体感染情况而异。然而，通常存在两种JHM特异性RNA，即核衣壳RNA和一种2.1 - 2.4×10⁶道尔顿的RNA种类。在接种后20天以后采集的脑和脊髓样本中，观察到JHM特异性RNA普遍减少；然而，JHM特异性RNA在这些大鼠的脊髓中持续存在的时间比在脑中更长。
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