Paggiaro P L, Loi A M, Rossi O, Ferrante B, Pardi F, Roselli M G, Baschieri L
Clin Allergy. 1984 Sep;14(5):463-9. doi: 10.1111/j.1365-2222.1984.tb02230.x.
The outcome of the respiratory symptoms, pulmonary function tests and bronchial hyperresponsiveness was studied in forty-seven workers with respiratory disease due to toluene diisocyanate (TDI) (twenty-seven asthmatic and twenty non-asthmatic subjects) after about 2 years from the first examination. Eight of twelve asthmatic subjects who left the industry after the first examination complained at the follow-up of dyspnoea and wheezing, but pulmonary function tests were unchanged; bronchial hyperresponsiveness decreased in three, but most were still positive to challenge test with bethanechol at the follow-up. Fifteen subjects who continued their exposure to TDI showed at the follow-up a significant decrease of the spirometric parameters and an increase of the bronchial hyperresponsiveness, and symptoms of chronic bronchitis were more frequent at the second examination. Non-asthmatic subjects, both exposed and non-exposed to TDI at the second examination, showed a significant decrease of the pulmonary function tests but no relevant changes in bronchial hyperresponsiveness. Our data suggest that stopping occupational exposure to TDI frequently did not produce an improvement of the TDI bronchial asthma, and persistence of the occupational exposure causes a more rapid decline in the respiratory function.
在首次检查约2年后，对47名因甲苯二异氰酸酯（TDI）患呼吸系统疾病的工人（27名哮喘患者和20名非哮喘患者）的呼吸道症状、肺功能测试和支气管高反应性结果进行了研究。首次检查后离开该行业的12名哮喘患者中有8名在随访时主诉呼吸困难和喘息，但肺功能测试无变化；3名患者的支气管高反应性降低，但大多数在随访时对氨甲酰甲胆碱激发试验仍呈阳性。15名继续接触TDI的受试者在随访时肺活量测定参数显著下降，支气管高反应性增加，第二次检查时慢性支气管炎症状更常见。第二次检查时接触和未接触TDI的非哮喘受试者肺功能测试均显著下降，但支气管高反应性无相关变化。我们的数据表明，停止职业性接触TDI通常不会改善TDI诱发的哮喘，而持续的职业性接触会导致呼吸功能更快下降。
