Charalambous B M, Webster D J, Mir M A
Clin Chim Acta. 1984 Aug 31;141(2-3):189-95. doi: 10.1016/0009-8981(84)90010-x.
To determine whether muscle sodium-potassium-ATPase activity, an expression of energy turnover, is increased in obesity, we studied a group of nine non-obese and seven obese subjects undergoing elective cholecystectomy. The muscle ATPase activity was 87 per cent higher (p less than 0.001) in obese subjects compared with non-obese subjects. The increase in the ATPase activity positively correlated with both the body mass index (r = 0.81) and excess body weight (r = 0.75). No relationship was found between erythrocyte and muscle sodium-potassium-ATPase activities (r = 0.25). These findings demonstrate an increased ATPase activity in skeletal muscle obtained from obese subjects and that the erythrocyte is an inaccurate marker of this enzyme with respect to other body tissue.
为了确定作为能量代谢指标的肌肉钠钾 -ATP 酶活性在肥胖症中是否升高，我们研究了一组 9 名非肥胖和 7 名肥胖的择期行胆囊切除术的受试者。与非肥胖受试者相比，肥胖受试者的肌肉 ATP 酶活性高 87%（p < 0.001）。ATP 酶活性的升高与体重指数（r = 0.81）和超重（r = 0.75）均呈正相关。红细胞和肌肉钠钾 -ATP 酶活性之间未发现相关性（r = 0.25）。这些发现表明，肥胖受试者骨骼肌中的 ATP 酶活性升高，并且就其他身体组织而言，红细胞是该酶的不准确标志物。
