Bolter C P, Critz J B
Arch Int Physiol Biochim. 1976 Feb;84(1):115-28. doi: 10.3109/13813457609072353.
In the pentobarbital-anaesthetized dog the effect of electrical stimulation of hindlimb skeletal muscles on thoracic and right duct lymph flow and enzyme content was examined. Increase in plasma creatine kinase (CK), L-aspartate-aminotransferase (AST) and lactic dehydrogenase (LDH) during 30-min muscle stimulation were not significantly altered by draining lymph. Both right duct and thoracic duct lymph flow trebled during stimulation. At the same time, the activity of the three enzymes examined decreased in right duct lymph and increased in thoracic duct lymph. Of the latter, only the increase in lymph CK was of a sufficient magnitude to have resulted in a detectable increase in plasma CK. CK was the smallest of the three enzymes studied and apparently preferentially entered the lymph, suggesting that the larger AST and LDH molecules were not likely to have entered the blood plasma directly from skeletal muscle. Rather their entry from some other tissue, possibly the formed elements of the blood, is indicated.
在戊巴比妥麻醉的犬中，研究了电刺激后肢骨骼肌对胸导管和右淋巴管淋巴流量及酶含量的影响。在30分钟的肌肉刺激过程中，血浆肌酸激酶（CK）、L-天冬氨酸转氨酶（AST）和乳酸脱氢酶（LDH）的增加并未因引流淋巴而发生显著改变。在刺激过程中，右淋巴管和胸导管的淋巴流量增加了两倍。同时，所检测的三种酶的活性在右淋巴管淋巴中降低，而在胸导管淋巴中升高。在后者中，只有淋巴CK的增加幅度足以导致血浆CK出现可检测到的增加。CK是所研究的三种酶中最小的，显然优先进入淋巴，这表明较大的AST和LDH分子不太可能直接从骨骼肌进入血浆。相反，表明它们是从其他一些组织进入的，可能是血液的有形成分。
