Aktas M, Auguste D, Lefebvre H P, Toutain P L, Braun J P
Department of Physiopathology, Ecole Nationale Vétérinaire, Toulouse, France.
Vet Res Commun. 1993;17(5):353-69. doi: 10.1007/BF01839386.
In the dog, creatine kinase (CK) is mostly present in the skeletal muscles, myocardium, brain and intestine. The MM isoenzyme predominates in muscles and myocardium. In plasma, reference values depend on the technique used and CK-MB accounts for about 30-45% of total CK activity. Sex has no influence on plasma CK activity, which is higher in young dogs than in adults. Plasma CK is elevated after physical exercise. After its release from the cells, CK reaches the plasma mostly via the lymphatic route and then remains in the plasma compartment. It is rapidly cleared with a half-life of about 2 hours. Muscle diseases are the main source of plasma CK elevations: inherited myopathies, malignant hyperthermia, hypothyroidism, vitamin E-selenium deficiency, prolonged decubitus, intramuscular injections, surgery, etc. Plasma CK is also increased in experimental myocardial infarction, for which the dog is an interesting model, allowing quantification of the damage by measuring the total CK activity released.
在犬类中，肌酸激酶（CK）主要存在于骨骼肌、心肌、脑和肠道中。MM同工酶在肌肉和心肌中占主导地位。在血浆中，参考值取决于所使用的技术，且CK-MB约占总CK活性的30%-45%。性别对血浆CK活性没有影响，幼犬的血浆CK活性高于成年犬。体育锻炼后血浆CK会升高。CK从细胞释放后，大多通过淋巴途径到达血浆，然后留在血浆中。它会迅速清除，半衰期约为2小时。肌肉疾病是血浆CK升高的主要来源：遗传性肌病、恶性高热、甲状腺功能减退、维生素E-硒缺乏、长期卧床、肌肉注射、手术等。在实验性心肌梗死中血浆CK也会升高，犬类是研究心肌梗死的一个有趣模型，通过测量释放的总CK活性可对损伤进行量化。
