人类甲状旁腺激素基因位点的限制性片段长度多态性
Restriction fragment length polymorphisms at the human parathyroid hormone gene locus.
作者信息
Schmidtke J, Pape B, Krengel U, Langenbeck U, Cooper D N, Breyel E, Mayer H
出版信息
Hum Genet. 1984;67(4):428-31. doi: 10.1007/BF00291404.
PMID:6092261
Abstract
Two common Pst I and Taq I restriction enzyme fragment length polymorphisms (RFLPs) were detected at the human parathyroid hormone (PTH) gene locus. The allele frequencies in a Northern German population were 0.578/0.422 (Pst I) and 0.628/0.372 (Taq I). The allele distributions follow Hardy-Weinberg expectations of equilibrium in the population. The Mendelian nature of the polymorphisms were confirmed in family studies.
摘要
在人类甲状旁腺激素（PTH）基因位点检测到两种常见的Pst I和Taq I限制性内切酶片段长度多态性（RFLP）。德国北部人群中的等位基因频率分别为0.578/0.422（Pst I）和0.628/0.372（Taq I）。等位基因分布符合该人群中哈迪-温伯格平衡预期。家系研究证实了这些多态性的孟德尔遗传特性。
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