一个家庭中的细小病毒感染与一对患遗传性球形红细胞增多症的患病同胞的再生障碍危象相关。
Parvovirus infection in a family associated with aplastic crisis in an affected sibling pair with hereditary spherocytosis.
作者信息
Green D H, Bellingham A J, Anderson M J
出版信息
J Clin Pathol. 1984 Oct;37(10):1144-6. doi: 10.1136/jcp.37.10.1144.
Abstract
There have been many reports of aplastic crisis preceded by a febrile illness in hereditary haemolytic anaemias. Recent research has shown that the human parvovirus may be a causative agent. We report on an adult sibling pair with hereditary spherocytosis who presented in aplastic crisis after a febrile illness. Both had evidence of recent parvovirus infection, shown by the presence of IgM class specific antibody in their sera. The children of one of the sibling pair, one of whom has hereditary spherocytosis but no chronic haemolysis, showed similar evidence of acute parvovirus infection.
摘要
在遗传性溶血性贫血中，有许多关于发热性疾病后发生再生障碍危象的报道。最近的研究表明，人细小病毒可能是致病因素。我们报告一对患有遗传性球形红细胞增多症的成年同胞，他们在发热性疾病后出现再生障碍危象。两人血清中均存在IgM类特异性抗体，表明近期有细小病毒感染。这对同胞中一人的孩子，其中一人患有遗传性球形红细胞增多症但无慢性溶血，也显示出急性细小病毒感染的类似证据。
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Hypothesis: the aplastic crisis of hereditary spherocytosis is due to a single transmissible agent.假说：遗传性球形红细胞增多症的再生障碍危象是由单一可传播因子引起的。
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Human parvovirus aplasia: case due to cross infection in a ward.人类细小病毒所致全血细胞减少症：病房内交叉感染病例
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