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J Virol. 1984 Nov;52(2):650-5. doi: 10.1128/JVI.52.2.650-655.1984.
2
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本文引用的文献

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CHEMICAL PHYSICAL PROPERTIES OF VIRTUALLY PURE FOOT-AND-MOUTH DISEASE VIRUS.近乎纯口蹄疫病毒的化学物理特性
Am J Vet Res. 1964 Mar;25:333-42.
2
Specific anti-influenza virus antibody production in vitro by human peripheral blood mononuclear cells.人外周血单个核细胞在体外产生特异性抗流感病毒抗体
J Immunol. 1981 Dec;127(6):2588-94.
3
The regulatory role of macrophages in antigenic stimulation. Part Two: symbiotic relationship between lymphocytes and macrophages.巨噬细胞在抗原刺激中的调节作用。第二部分：淋巴细胞与巨噬细胞之间的共生关系。
Adv Immunol. 1981;31:1-136. doi: 10.1016/s0065-2776(08)60919-0.
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Effect of the adjuvant dimethyl dioctadecyl ammonium bromide on the humoral and cellular immune responses to encephalomyocarditis virus.佐剂二甲基二十八烷基溴化铵对脑心肌炎病毒体液免疫和细胞免疫反应的影响。
Antiviral Res. 1983 Sep;3(3):137-49. doi: 10.1016/0166-3542(83)90021-9.
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Differentiation of foot-and-mouth disease virus strains using a competition enzyme-linked immunosorbent assay.
J Virol Methods. 1982 Jan;3(6):355-65. doi: 10.1016/0166-0934(82)90040-4.
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Thermal stability of foot-and-mouth disease virus.口蹄疫病毒的热稳定性
Arch Virol. 1981;70(1):21-32. doi: 10.1007/BF01320790.
7
Detection and quantification of IgM, IgA, IgG1 and IgG2 antibodies against foot-and-mouth disease virus from bovine sera using an enzyme-linked immunosorbent assay.使用酶联免疫吸附测定法检测和定量牛血清中针对口蹄疫病毒的IgM、IgA、IgG1和IgG2抗体。
J Hyg (Lond). 1981 Feb;86(1):79-85. doi: 10.1017/s0022172400068765.
8
Induction of antigen-specific antibody response in human peripheral blood lymphocytes in vitro by a dog kidney cell vaccine against rabies virus (DKCV).
J Immunol. 1983 Sep;131(3):1234-9.
9
In vitro influenza virus-specific antibody production in man: antigen-specific and HLA-restricted induction of helper activity mediated by cloned human T lymphocytes.人源体外流感病毒特异性抗体的产生：克隆化人T淋巴细胞介导的辅助活性的抗原特异性及HLA限制性诱导
J Immunol. 1982 Oct;129(4):1465-70.
10
In vitro antigen-induced, antigen-specific antibody production in man. Specific and polyclonal components, kinetics, and cellular requirements.人体外抗原诱导的抗原特异性抗体产生。特异性和多克隆成分、动力学及细胞需求。
J Exp Med. 1981 Oct 1;154(4):1043-57. doi: 10.1084/jem.154.4.1043.

在预先致敏的小鼠脾细胞培养物中诱导对口蹄疫病毒的抗体

Induction of antibody to foot-and-mouth disease virus in presensitized mouse spleen cell cultures.

作者信息

Collen T, McCullough K C, Doel T R

出版信息

J Virol. 1984 Nov;52(2):650-5. doi: 10.1128/JVI.52.2.650-655.1984.

DOI:10.1128/JVI.52.2.650-655.1984
PMID:6092687
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC254569/
Abstract

Cultures of spleen cells from immunized mice were stimulated in vitro by soluble preparations of purified foot-and-mouth disease virus. Virus-specific antibody, as detected by an enzyme-linked immunosorbent assay, was produced by immune spleen cells but not by normal, nonimmune cells. The optimal specific response was obtained with 1 microgram of virus per ml of culture; as the virus concentration was increased, the production of specific antibody was reduced. For very low concentrations of virus (less than 0.01 microgram per culture), there was tentative evidence of suppression of the specific antibody response. The levels of specific antibody induced were dependent on the source and number of plastic-adherent cells present in the cultures. We intend to use this model system to study further the basis of immunity to foot-and-mouth disease virus.

摘要

用纯化的口蹄疫病毒可溶性制剂在体外刺激免疫小鼠的脾细胞培养物。通过酶联免疫吸附测定法检测到，病毒特异性抗体由免疫脾细胞产生，而非正常的非免疫细胞。每毫升培养物中加入1微克病毒可获得最佳特异性反应；随着病毒浓度增加，特异性抗体的产生减少。对于极低浓度的病毒（每培养物少于0.01微克），有初步证据表明特异性抗体反应受到抑制。诱导产生的特异性抗体水平取决于培养物中塑料贴壁细胞的来源和数量。我们打算利用这个模型系统进一步研究对口蹄疫病毒免疫的基础。