Rutledge J, Beckwith J B, Benjamin D, Haas J E
Pediatr Pathol. 1983 Jan-Mar;1(1):93-8. doi: 10.3109/15513818309048287.
Malignant rhabdoid tumor of the kidney, a clinically and pathologically unique tumor of early childhood, has been recently distinguished from nephroblastoma. Skeletal muscle histogenesis has been considered because of its aggressive course and histologic resemblance to rhabdomyosarcoma. Application of an indirect immunoperoxidase technique for myoglobin, an early marker of myogenesis, failed to show the protein in four malignant rhabdoid tumors of kidney. This substantiates the lack of ultrastructural evidence of skeletal muscle differentiation in these tumors.
肾恶性横纹肌样瘤是一种临床和病理上独特的儿童早期肿瘤，最近已与肾母细胞瘤区分开来。由于其侵袭性病程以及在组织学上与横纹肌肉瘤相似，人们一直认为它起源于骨骼肌。应用间接免疫过氧化物酶技术检测肌红蛋白（一种肌发生的早期标志物），结果显示在4例肾恶性横纹肌样瘤中均未检测到该蛋白。这证实了这些肿瘤缺乏骨骼肌分化的超微结构证据。
