Brooks J J
Cancer. 1982 Nov 1;50(9):1757-63. doi: 10.1002/1097-0142(19821101)50:9<1757::aid-cncr2820500919>3.0.co;2-5.
Myoglobin, found exclusively in striated muscle, can be considered a fetal antigen. This study investigated its usefulness as a tumor marker for rhabdomyosarcoma (RMS) using an immunoperoxidase technique. Eight-nine percent (89%) or 27 rhabdomyosarcomas contained immunoreactive myoglobin. In contrast, all other soft tissue tumors (54), carcinomas (10), and numerous normal tissues including smooth muscle were negative. Among RMS, staining correlated directly with cytoplasmic differentiation regardless of histologic type. Importantly, six of nine small cell RMS with no initially appreciated cytoplasm were positive, although focally. Since the three negative RMS had only limited tissue available for study, it remains possible that all RMS would exhibit rare positivity if sizeable specimens were tested. Myoglobin should be considered an extremely sensitive and specific tissue tumor marker for rhabdomyosarcoma of considerable clinical importance.
肌红蛋白仅存在于横纹肌中，可被视为一种胎儿抗原。本研究采用免疫过氧化物酶技术，调查了其作为横纹肌肉瘤（RMS）肿瘤标志物的效用。89%（27例）横纹肌肉瘤含有免疫反应性肌红蛋白。相比之下，所有其他软组织肿瘤（54例）、癌（10例）以及包括平滑肌在内的众多正常组织均为阴性。在横纹肌肉瘤中，无论组织学类型如何，染色都与细胞质分化直接相关。重要的是，9例最初未发现有细胞质的小细胞横纹肌肉瘤中有6例呈阳性，尽管是局灶性的。由于3例阴性横纹肌肉瘤仅有有限的组织可供研究，如果检测大量标本，所有横纹肌肉瘤都有可能呈现罕见的阳性反应。肌红蛋白应被视为横纹肌肉瘤极其敏感和特异的组织肿瘤标志物，具有相当重要的临床意义。
