Anttila S, Sutinen S, Pääkkö P, Alapieti T, Peura R, Sivonen S J
Br J Ind Med. 1984 Nov;41(4):468-73. doi: 10.1136/oem.41.4.468.
The right upper lung lobe of a 74 year old man was resected for a central tumour. Two primary cancers were found; a central small cell carcinoma and a peripheral squamous cell carcinoma. In addition, the peripheral lung tissue showed generalised peribronchiolar fibrosis extending from the non-respiratory bronchioles to the level of the alveolar ducts. Abundant asbestos bodies and large amounts of black dust were seen around the bronchioles. Pulmonary mineral particles were studied by quantitative energy dispersive x ray microanalysis (EDS) using scanning transmission electron microscopy (STEM). The x ray spectra for mineral particles were measured in thin sections, and the characteristic peak intensities of the elements were converted to weight fractions (in oxides). The results enabled the minerals present to be identified and their presence confirmed by calculating the mineral formula. These originated from nine natural minerals, anthophyllite and chrysotile asbestos, talc, and quartz, feldspars, and muscovite, which are components of sand, and also from two artificial mullites used in fire clay. The exposure history of the patient explained the most likely origins of the minerals detected. The patient had been a mason for 23 years, repairing and demolishing stoves and fireplaces and using asbestos for insulation work.
一名74岁男性因中央型肿瘤接受了右上肺叶切除术。术中发现了两种原发性癌症，一种是中央型小细胞癌，另一种是周围型鳞状细胞癌。此外，周围肺组织显示出从非呼吸性细支气管延伸至肺泡管水平的广泛性细支气管周围纤维化。在细支气管周围可见大量石棉小体和大量黑色粉尘。使用扫描透射电子显微镜（STEM）通过能量色散X射线微分析（EDS）对肺内矿物颗粒进行了定量研究。在薄片中测量矿物颗粒的X射线光谱，并将元素的特征峰强度转换为重量分数（以氧化物形式）。通过计算矿物分子式，这些结果能够识别出存在的矿物并证实其存在。这些矿物来源于九种天然矿物，直闪石和温石棉、滑石、石英、长石和白云母，它们是沙子的成分，还来源于耐火粘土中使用的两种人造莫来石。患者的接触史解释了所检测到的矿物的最可能来源。该患者曾做过23年泥瓦匠，从事炉灶和壁炉的维修与拆除工作，并使用石棉进行隔热作业。
