Terzakis J A
Department of Pathology, Lenox Hill Hospital, New York, New York, 10021-1883 USA.
Ultrastruct Pathol. 1995 May-Jun;19(3):167-73. doi: 10.3109/01913129509064218.
A total of 15 cases of peripherally located lung carcinomas associated with scar (scar carcinoma) were studied by light microscopy and electron microscopy with energy-dispersive X-ray microanalysis (XMA). Results were compared to those of three autopsy lungs without significant pulmonary findings that served as controls. Fibrosis with scar formation characterized the 15 tumor cases. Particulate depositions including doubly refractile particles were also increased in the tumor group. XMA identified 25 elements with great complexity of particulate composition. Silicon was the most prominent element and was found in 16 of 18 cases studied. Kaolinite, feldspar, talc, muscovite, and silica were recognized. The fibrogenic properties of silicate compounds were emphasized, including their prominence in the lung tumor group. While the important concept of tumor desmoplasia was recognized, the study showed significant fibrosis in relation to fibrogenic materials, which undoubtedly preceded the appearance of the tumors. Also noted were the carcinogens uranium, cadmium, chromium, nickel, and arsenic, some of which were previously described as minor constituents of naturally occurring minerals.
对15例伴有瘢痕的周围型肺癌（瘢痕癌）进行了光镜检查，并采用能量色散X射线微分析（XMA）进行了电子显微镜检查。将结果与3例无明显肺部病变的尸检肺进行比较，后者作为对照。15例肿瘤病例均有瘢痕形成的纤维化表现。肿瘤组中包括双折射颗粒在内的颗粒沉积也有所增加。XMA鉴定出25种元素，颗粒成分非常复杂。硅是最主要的元素，在所研究的18例中有16例发现硅。还识别出了高岭石、长石、滑石、白云母和二氧化硅。强调了硅酸盐化合物的促纤维化特性，包括它们在肺肿瘤组中的突出表现。虽然认识到肿瘤促结缔组织增生这一重要概念，但研究表明，与促纤维化物质相关的显著纤维化无疑先于肿瘤出现。还注意到了致癌物铀、镉、铬、镍和砷，其中一些以前被描述为天然矿物的次要成分。
