Hanke W, Sepulveda M J, Watson A, Jankovic J
Br J Ind Med. 1984 Nov;41(4):474-9. doi: 10.1136/oem.41.4.474.
Medical and environmental surveys were conducted at a wollastonite mine and mill in 1976 and in 1982. Health testing included chest radiography, spirometry, and a questionnaire. Workers at a nearby electronics plant were also examined in 1982 for a comparison of lung function and respiratory symptoms. Both wollastonite and control workers showed significant smoking effects for chronic respiratory symptoms, but differences between the groups were not detected. Pneumoconiosis was found in 3% (3/108) of the wollastonite workers in 1982, but none showed a significant progression from their 1976 radiographs. The lung function tests of the 108 wollastonite workers examined in 1982 showed dust related changes in FEV1, FEV1/FVC ratio, and peak flow rate which were independent of age, height, and smoking habit (p less than 0.01). For non-smokers alone, only the FEV1/FVC ratio declined significantly with dust-years of exposure (p less than 0.01). The comparison of lung function in 1982 between a high dust exposed subgroup of wollastonite workers and the control population showed a significantly lower FEV1/FVC ratio and peak flow rate in the study group (p less than 0.05). Analysis of 1976-82 changes in pulmonary function showed that wollastonite workers with higher dust exposure had a significantly greater decline in peak flow over the period than workers with lower exposures (p less than 0.01). These data suggest that long term cumulative exposure to wollastonite may impair ventilatory capacity as reflected by changes in the FEV1/FVC ratio and peak flow rate.
1976年和1982年,在一家硅灰石矿场及加工厂开展了医学和环境调查。健康检测包括胸部X光检查、肺功能测定以及问卷调查。1982年,还对附近一家电子厂的工人进行了检查,以比较肺功能和呼吸道症状。硅灰石工人和对照组工人在慢性呼吸道症状方面均显示出显著的吸烟影响,但未检测到两组之间的差异。1982年,在3%(3/108)的硅灰石工人中发现了尘肺病,但与1976年的X光片相比,无人显示出明显进展。1982年接受检查的108名硅灰石工人的肺功能测试显示,第一秒用力呼气量(FEV1)、FEV1/用力肺活量(FVC)比值和峰值流速出现了与粉尘相关的变化,这些变化与年龄、身高和吸烟习惯无关(p<0.01)。仅对于不吸烟者,FEV1/FVC比值仅随接触粉尘年限显著下降(p<0.01)。1982年,对硅灰石工人中高粉尘暴露亚组与对照组人群的肺功能进行比较,结果显示研究组的FEV1/FVC比值和峰值流速显著较低(p<0.05)。对1976 - 1982年肺功能变化的分析表明,粉尘暴露较高的硅灰石工人在此期间的峰值流速下降幅度明显大于暴露较低的工人(p<0.01)。这些数据表明,长期累积接触硅灰石可能会损害通气能力,这可通过FEV1/FVC比值和峰值流速的变化反映出来。