Moulin J J, Wild P, Mur J M, Caillard J F, Massin N, Meyer-Bisch C, Toamain J P, Hanser P, Liet S, Du Roscoat M N
Institut National de Recherche et de Sécurité Service d'épidmiologie, Vandoeuvre Lès Nancy, France.
Int Arch Occup Environ Health. 1988;61(3):171-8. doi: 10.1007/BF00381015.
A respiratory health questionnaire was administered to the workers producing man-made mineral fibers in three glasswool and two rockwool plants in France, in order to detect adverse effects resulting from fiber exposure. The mean ages of the 2024 male participants ranged from 32 to 41 years. The standardized questionnaire was filled in by the industrial physicians: occupational history, smoking habits, respiratory symptoms (cough, phlegm, dyspnea, asthma), irritative complaints of the upper airways (nasal fossae and sinuses, pharynx and larynx) were all recorded. Multiple unconditional logistic regression was used to test for a relationship between possible explanatory variables and these symptoms. The prevalence of respiratory symptoms (cough, phlegm, dyspnea) was strongly correlated with age and increased markedly among current smokers. Having adjusted for these confounding factors, significantly elevated Odds Ratios (ORs) for cough and phlegm were observed among the workers of one plant (51% of the whole study population) who had been exposed to fibers for a long time. In the same plant, the ORs for complaints of nasal fossae and sinuses increased significantly with the duration of fiber exposure, and one elevated OR was observed for pharyngeal and laryngeal symptoms. These findings were not consistent with the results observed in the four other plants (49% of the study population), since ORs for all these symptoms were either low or not significantly increased according to the duration of fiber exposure. This lack of similarity among plants could be explained either by differences in interviewers, age, seniority and tobacco consumption, or by secular changes in the industrial processes involved.(ABSTRACT TRUNCATED AT 250 WORDS)
为了检测纤维暴露所产生的不良影响,对法国三家玻璃棉厂和两家岩棉厂生产人造矿物纤维的工人进行了呼吸健康问卷调查。2024名男性参与者的平均年龄在32岁至41岁之间。这份标准化问卷由工业医师填写:职业史、吸烟习惯、呼吸道症状(咳嗽、咳痰、呼吸困难、哮喘)以及上呼吸道(鼻窝和鼻窦、咽和喉)的刺激症状均有记录。采用多因素非条件logistic回归分析可能的解释变量与这些症状之间的关系。呼吸道症状(咳嗽、咳痰、呼吸困难)的患病率与年龄密切相关,且在当前吸烟者中显著增加。在对这些混杂因素进行校正后,在一家工厂(占整个研究人群的51%)中长期接触纤维的工人中,咳嗽和咳痰的比值比(OR)显著升高。在同一家工厂中,鼻窝和鼻窦症状的OR随着纤维暴露时间的延长而显著增加,咽部和喉部症状也观察到一个升高的OR。这些发现与其他四家工厂(占研究人群的49%)的结果不一致,因为根据纤维暴露时间,所有这些症状的OR要么很低,要么没有显著增加。工厂之间缺乏相似性可能是由于访谈者、年龄、工龄和烟草消费的差异,或者是由于所涉及的工业过程的长期变化所致。(摘要截选至250字)