Hehlmann R, Erfle V, Schetters H, Luz A, Rohmer H, Schreiber M A, Pralle H, Essers U, Weber W
Cancer. 1984 Dec 15;54(12):2927-35. doi: 10.1002/1097-0142(19841215)54:12<2927::aid-cncr2820541219>3.0.co;2-3.
Human sera contain antigens and also circulating immune complexes that are related to the primate retroviral envelope glycoprotein gp70 of simian sarcoma/simian sarcoma associated virus (SiSV) and of gibbon ape leukemia virus (GaLV). SiSVgp70 related antigens (AG) and immune complexes (IC) are detected both in leukemic and in nonleukemic sera. In a further analysis of these data, the prognostic significance of SiSVgp70 related AG and IC in leukemic patients was examined. The data show that the presence of SiSVgp70 related AG and IC indicates an unfavorable clinical course and a shorter survival time in acute leukemias (AL) and in chronic myelogenous leukemia in blast crisis (CML-BC). Survival data of 56 of 64 patients tested were analyzed (38 patients with AL and 18 patients with CML-BC). Patients with AL whose sera were positive for SiSVgp70 related AG and IC had a median survival time of 9.5 months after diagnosis versus 16 months for patients negative for such AG and IC. This difference in survival time was more pronounced for patients with acute nonlymphocytic leukemia (ANLL) (6.5 versus 19 months). The difference in survival between SiSVgp70 related AG- and IC-negative and positive groups as tested by life table analysis (log-rank test) is significant (P less than 0.05). Patients with AL of the AG- and/or IC-positive group had fewer complete remissions. Patients who had no remissions belong to the AG- and/or IC-positive group (P = 0.06). Patients with CML-BC whose sera were positive for SiSVgp70 related AG and/or IC had a median survival time of 2 months after diagnosis versus 7 months for patients with sera negative for such AG and IC. As tested by log-rank test, survival curves between the two groups are significantly different (P less than 0.05). These findings suggest that SiSVgp70 related AG and IC may play an important role in the course of acute leukemia and can provide useful prognostic information.
人血清中含有抗原以及循环免疫复合物，这些物质与猿猴肉瘤/猿猴肉瘤相关病毒（SiSV）和长臂猿白血病病毒（GaLV）的灵长类逆转录病毒包膜糖蛋白gp70有关。在白血病和非白血病血清中均检测到与SiSVgp70相关的抗原（AG）和免疫复合物（IC）。在对这些数据的进一步分析中，研究了白血病患者中与SiSVgp70相关的AG和IC的预后意义。数据显示，与SiSVgp70相关的AG和IC的存在表明急性白血病（AL）和慢性粒细胞白血病急变期（CML-BC）的临床病程不利且生存时间较短。对64例检测患者中的56例（38例AL患者和18例CML-BC患者）的生存数据进行了分析。血清中与SiSVgp70相关的AG和IC呈阳性的AL患者诊断后的中位生存时间为9.5个月，而此类AG和IC呈阴性的患者为16个月。急性非淋巴细胞白血病（ANLL）患者的生存时间差异更为明显（6.5个月对19个月）。通过生命表分析（对数秩检验）测试，与SiSVgp70相关的AG和IC阴性与阳性组之间的生存差异具有显著性（P小于0.05）。AG和/或IC阳性组的AL患者完全缓解的次数较少。未缓解的患者属于AG和/或IC阳性组（P = 0.06）。血清中与SiSVgp70相关的AG和/或IC呈阳性的CML-BC患者诊断后的中位生存时间为2个月，而此类AG和IC呈阴性的患者为7个月。通过对数秩检验，两组之间的生存曲线有显著差异（P小于0.05）。这些发现表明，与SiSVgp70相关的AG和IC可能在急性白血病病程中起重要作用，并可提供有用的预后信息。
