Karhunen M, Koskela O, Hannelin M
Br J Obstet Gynaecol. 1980 Jan;87(1):70-2. doi: 10.1111/j.1471-0528.1980.tb04429.x.
A single dose of 2 g tinidazole was given preoperatively to 70 patients undergoing elective hysterectomy; 76 patients served as controls. One patient in the drug therapy group and 10 in the control group had a temperature of 38 degrees C at some time after the first postoperative day. One patient in the tinidazole group and seven among the controls had abscess formation. The differences between the tinidazole and the control groups were highly significant. This simple prophylactic procedure reduced treatment costs and minimised infection following hysterectomy.
对70例行择期子宫切除术的患者术前给予单剂量2克替硝唑；76例患者作为对照。药物治疗组有1例患者，对照组有10例患者在术后第一天后的某个时间体温达到38摄氏度。替硝唑组有1例患者，对照组有7例患者形成脓肿。替硝唑组和对照组之间的差异非常显著。这种简单的预防措施降低了治疗成本，并将子宫切除术后的感染降至最低。
