Bell E J, McCartney R A
J Hyg (Lond). 1984 Oct;93(2):197-203. doi: 10.1017/s0022172400064718.
The results of a twelve-year study of Coxsackie B virus (CBV) infections in patients with a variety of acute and chronic illnesses are reported. CBVs were isolated from only 123 patients most of whom were children with respiratory illness. Virus diagnosis in adults was based mainly on the detection of significant rising or static high neutralizing antibody titres. Between 1972 and 1979 most investigations centred on patients with suspected viral heart disease, 12% of whom were found to have diagnostically significant CBV titres. In studies on patients with definite myo-pericarditis the number positive increased to 33%. In 1980 clinical interest switched to the possible role of CBV in myalgic encephalomyelitis (ME), an illness of diverse symptomatology. Investigation of suspected cases of ME in 1983 showed that 16% were serologically positive compared to 4% of normal adults in the West of Scotland. In patients with well-documented ME this figure rose to 41%. The demand by clinicians for CBV neutralizing antibody tests has increased over the past twelve years and continues to escalate annually, especially in patients with chronic relapsing illness.
报告了一项针对患有各种急慢性疾病患者的柯萨奇B病毒（CBV）感染的十二年研究结果。仅从123名患者中分离出CBV，其中大多数是患有呼吸道疾病的儿童。成人的病毒诊断主要基于检测到显著上升或持续高水平的中和抗体滴度。1972年至1979年间，大多数研究集中在疑似病毒性心脏病患者身上，其中12%被发现具有诊断意义的CBV滴度。在对确诊的心肌心包炎患者的研究中，阳性人数增加到33%。1980年，临床兴趣转向CBV在肌痛性脑脊髓炎（ME）中的可能作用，这是一种症状多样的疾病。1983年对疑似ME病例的调查显示，与苏格兰西部4%的正常成年人相比，16%的患者血清学呈阳性。在有充分记录的ME患者中，这一数字上升到41%。在过去十二年中，临床医生对CBV中和抗体检测的需求不断增加，并且每年持续上升，尤其是在患有慢性复发性疾病的患者中。
