Schoub B D, Johnson S, McAnerney J M, Dos Santos I L, Klaassen K I
J Hyg (Lond). 1985 Oct;95(2):447-55. doi: 10.1017/s0022172400062872.
A particularly extensive epidemic of Coxsackie B3 virus infection occurred in Johannesburg in the spring and summer of 1984. A total of 142 positive cases were diagnosed by isolation of the virus from stools and other specimens (60) or by serology (82). Coxsackie B3 accounted for 87% of the isolations and was also the dominant serotype on serology. The outbreak involved predominantly children and young adults, with no apparent sex differences being noted. The majority of specimens came from the white population and no significant difference in age or sex distribution could be observed between the two race groups. The major clinical presentation in the white group was Bornholm disease followed by cardiac involvement and then meningoencephalitis. In the black group, however, myocarditis was the major clinical presentation, which is of particular interest taking into account the extremely high incidence of acute rheumatic carditis in this population and the prevalence of chronic cardiomyopathy.
1984年春夏，约翰内斯堡爆发了一场特别广泛的柯萨奇B3病毒感染疫情。通过从粪便和其他标本（60例）中分离病毒或血清学检测（82例），共诊断出142例阳性病例。柯萨奇B3病毒占分离出病毒的87%，也是血清学检测中的主要血清型。此次疫情主要涉及儿童和年轻人，未发现明显的性别差异。大多数标本来自白人，两个种族群体在年龄或性别分布上没有显著差异。白人组的主要临床表现是波恩霍尔姆病，其次是心脏受累，然后是脑膜脑炎。然而，在黑人组中，心肌炎是主要临床表现，鉴于该人群中急性风湿性心脏病的极高发病率和慢性心肌病的患病率，这一点尤其值得关注。
