Gidoni D, Dynan W S, Tjian R
Nature. 1984;312(5993):409-13. doi: 10.1038/312409a0.
The human transcription factor Sp1 binds upstream of certain viral and cellular promoters and activates initiation of RNA synthesis from these promoters by RNA polymerase II. The Sp1 binding sites of both simian virus 40 and a related monkey promoter contain multiple copies of the sequence GGGCGG, three or four of these sequences forming close contacts with Spl. The clustered contacts fall on one strand of the DNA and are arranged similarly in the major groove of the DNA helix in both promoters.
人类转录因子Sp1结合在某些病毒和细胞启动子的上游，并通过RNA聚合酶II激活这些启动子的RNA合成起始。猿猴病毒40和一个相关的猴启动子的Sp1结合位点都包含序列GGGCGG的多个拷贝，其中三到四个这样的序列与Sp1形成紧密接触。这些成簇的接触位于DNA的一条链上，并且在两个启动子的DNA螺旋大沟中的排列方式相似。
