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一种被LTR元件中断的新型转座子样重复序列出现在小鼠c-mos基因座的B1重复序列簇中。

A novel transposon-like repeat interrupted by an LTR element occurs in a cluster of B1 repeats in the mouse c-mos locus.

作者信息

Propst F, Vande Woude G F

出版信息

Nucleic Acids Res. 1984 Nov 26;12(22):8381-92. doi: 10.1093/nar/12.22.8381.

DOI:10.1093/nar/12.22.8381
PMID:6095198
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC320374/
Abstract

The mouse genomic locus containing the oncogene c-mos was analyzed for repetitive DNA sequences. We found a single B1 repeat 10 kb upstream and three B1 repeats 0.6 kb, 2.7 kb, and 5.4 kb, respectively, downstream from c-mos. The B1 repeat closest to c-mos contains an internal 7-bp duplication and a 18-bp insertion. Localized between the last two B1 repeats is a copy of a novel mouse repeat. Sequence comparison of three copies of this novel repeat family shows that they a) contain a conserved BglII site, b) are approximately 420 bp long, c) possess internal 50-bp polypurine tracts, and d) have structural characteristics of transposable elements. They are present in about 1500 copies per haploid genome in the mouse, but are not detectable in DNA of other mammals. The BglII repeat downstream from c-mos is interrupted by a single 632-bp LTR element. We estimate that approximately 1200 copies of this element are present per haploid genome in BALB/c mice. It shares sequence homology in the R-U5 region with an LTR element found in 129/J mice.

摘要

对包含癌基因c-mos的小鼠基因组位点进行了重复DNA序列分析。我们在c-mos上游10 kb处发现了一个单一的B1重复序列，在其下游分别有三个B1重复序列，距离分别为0.6 kb、2.7 kb和5.4 kb。最靠近c-mos的B1重复序列包含一个内部7 bp的重复和一个18 bp的插入。在最后两个B1重复序列之间定位着一个新的小鼠重复序列的拷贝。对这个新重复序列家族的三个拷贝进行序列比较表明，它们：a）包含一个保守的BglII位点；b）长度约为420 bp；c）具有内部50 bp的多聚嘌呤序列；d）具有转座元件的结构特征。它们在小鼠单倍体基因组中约有1500个拷贝，但在其他哺乳动物的DNA中无法检测到。c-mos下游的BglII重复序列被一个单一的632 bp的LTR元件打断。我们估计在BALB/c小鼠的单倍体基因组中约有1200个该元件的拷贝。它在R-U5区域与在129/J小鼠中发现的一个LTR元件具有序列同源性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7ad/320374/21f157d75165/nar00340-0106-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7ad/320374/78ff827b2bbd/nar00340-0104-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7ad/320374/21f157d75165/nar00340-0106-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7ad/320374/78ff827b2bbd/nar00340-0104-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7ad/320374/21f157d75165/nar00340-0106-a.jpg

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引用本文的文献

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A novel retroviruslike family in mouse DNA.小鼠DNA中的一个新的类逆转录病毒家族。
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Transduction of host cellular sequences by a retroviral shuttle vector.逆转录病毒穿梭载体对宿主细胞序列的转导

本文引用的文献

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Nucleic Acids Res. 1982 Jan 11;10(1):279-94. doi: 10.1093/nar/10.1.279.
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Translocations among antibody genes in human cancer.人类癌症中抗体基因之间的易位。
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'Solo' large terminal repeats (LTR) of an endogenous retrovirus-like gene family (VL30) in the mouse genome.小鼠基因组中一个内源性逆转录病毒样基因家族（VL30）的“单独”大末端重复序列（LTR）
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