Fryer J, Lederis K, Rivier J
Peptides. 1984 Sep-Oct;5(5):925-30. doi: 10.1016/0196-9781(84)90118-9.
The structurally homologous peptides urotensin I, ovine CRF and sauvagine stimulate the release of immunoreactive ACTH from a superfused dispersed goldfish anterior pituitary cell column. The addition of cortisol to the superfusion buffer resulted, following a latent period, in a decrease in basal release of ACTH from the pituitary cell column and a diminution in the ACTH-releasing activities of urotensin I, CRF and sauvagine. The removal of cortisol from the superfusion buffer resulted in a slow recovery of basal ACTH release and a recovery of the ACTH-releasing activities of urotensin I, CRF and sauvagine. These results are supportive of the view that urotensin I, or a urotensin I-like peptide, serves as a physiological regulator of ACTH release in teleost fishes.
结构同源的肽类，如尾加压素I、羊促肾上腺皮质激素释放因子（oCRF）和蛙皮素，可刺激经超灌注的分散金鱼垂体前叶细胞柱释放免疫反应性促肾上腺皮质激素（ACTH）。在超灌注缓冲液中添加皮质醇后，经过一段潜伏期，垂体细胞柱ACTH的基础释放量减少，尾加压素I、oCRF和蛙皮素的促ACTH释放活性降低。从超灌注缓冲液中去除皮质醇后，ACTH基础释放量缓慢恢复，尾加压素I、oCRF和蛙皮素的促ACTH释放活性也恢复。这些结果支持了这样一种观点，即尾加压素I或类尾加压素I肽在硬骨鱼类中作为ACTH释放的生理调节因子。
