五乙酰基洋地黄毒苷：强心苷系列中前体药物的原型。
Penta-acetyl-gitoxin: the prototype of a prodrug in the cardiac glycoside series.
作者信息
Megges R, Portius H J, Repke K R
出版信息
Pharmazie. 1977 Nov;32(11):665-7.
PMID:609583
Abstract
Penta-acetyl-gitoxin is a suitable prodrug of gitoxin since it shows--side-effect latentiation, due to its inactive application form;--bioavailability, due to its improved solubility and thus good enteral absorption and--bioactivation, due to rapid de-acetylation in the body after absorption.
摘要
五乙酰基洋地黄毒苷是洋地黄毒苷的一种合适的前药，因为它具有以下特点：——由于其非活性的应用形式，表现出副作用潜伏性；——由于其溶解性提高，因而具有良好的肠道吸收，表现出生物利用度；——由于吸收后在体内迅速脱乙酰化，表现出生物活化作用。
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