放线菌酮对细胞核中泛素化组蛋白H2A含量的影响。
The effect of cycloheximide on nuclear uH2A content.
作者信息
Dalay N, Kirdar B, Bermek E
出版信息
Experientia. 1984 Dec 15;40(12):1398-9. doi: 10.1007/BF01951910.
PMID:6096161
Abstract
The effect of intraperitonal cycloheximide administration on acid-soluble rat liver chromatin proteins has been investigated by electrophoresis in acetic acid-urea polyacrylamide gels. A nonhistone protein, which migrates between oxidized histone H3 and histone H1 has been found to be increased in amount following cycloheximide treatment. This protein seems to be identical with semihistone protein H24 (uH2A). A possible relationship of uH2A to the inhibition of rRNA synthesis is discussed.
摘要
通过在醋酸 - 尿素聚丙烯酰胺凝胶中进行电泳，研究了腹腔注射放线菌酮对大鼠肝脏酸性可溶染色质蛋白的影响。发现一种在氧化组蛋白H3和组蛋白H1之间迁移的非组蛋白，在放线菌酮处理后其含量增加。这种蛋白质似乎与半组蛋白H24（uH2A）相同。讨论了uH2A与rRNA合成抑制之间的可能关系。
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引用本文的文献
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Binding of protein uH2A and histone H2A to DNA.蛋白质uH2A和组蛋白H2A与DNA的结合。
Cell Biophys. 1989 Feb;14(1):43-51. doi: 10.1007/BF02797390.
本文引用的文献
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Effects of actinomycin D and cycloheximide on the nucleolar ultrastructure of porcine oocytes.放线菌素D和环己酰亚胺对猪卵母细胞核仁超微结构的影响。
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The effect of isoproterenol and hydroxyurea on the presence of ubiquitin and protein A24 in the rat salivary gland.异丙肾上腺素和羟基脲对大鼠唾液腺中泛素和蛋白A24存在情况的影响。
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Increases in protein A24 following treatment of Ehrlich ascites tumor cells with 1-methyl-1-nitrosourea and 1,3-bis(2-chloroethyl)-1-nitrosourea.用1-甲基-1-亚硝基脲和1,3-双（2-氯乙基）-1-亚硝基脲处理艾氏腹水瘤细胞后，蛋白质A24增加。
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Proc Natl Acad Sci U S A. 1981 Feb;78(2):761-5. doi: 10.1073/pnas.78.2.761.
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J Biol Chem. 1980 Nov 25;255(22):10555-8.
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